Publications

2021 2020 2019 2018 2017 2016 2015 2014 2013 2012   Past activity
2022


4. Rejc L, Gómez-Vallejo V, Joya A, Arsequell G, Egimendia A, Castellnou P, Ríos-Anglada X Cossío U, Baz Z, Iglesias L, Capetillo-Zarate E, Ramos-Cabrer P, Martin A, Llop J.
Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography
Chem. Sci, 14:80
3. Jiang L, Sarró P, Teo WJ, Llop J, Suero M.
Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters
Chem. Sci, 13:4327
2. Ramírez MdlA, Martínez-Villacorta Á.M, Gómez-Vallejo V, Andreozzi P, Soler-Illia G, Llop J, Moya SE.
Core vs. surface labelling of mesoporous silica nanoparticles: advancing the understanding of nanoparticle fate and design of labelling strategies
Nanoscale Adv, 4(9):2049-2234
1. Lopez-Fabuel I, Garcia-Macia M, Buondelmonte C, Burmistrova O, Bonora N, Alonso-Batan P, Morant-Ferrando B, Vicente-Gutierrez C, Jimenez-Blasco D, Quintana-Cabrera R, Fernandez E, Llop J, Ramos-Cabrer P, Sharaireh A, Guevara-Ferrer M, Fitzpatrick L, Thompton CD, McKay TR, Storch S, Medina DL, Mole SE, Fedichev PO, Almeida A, Bolaños JP.
Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis
Nat. Commun , 13:536
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2021


18. Pulagam KR, Henriksen-Lacey M, Uribe KB, Renero-Lecuna C, Kumar J, Charalampopoulou A, Facoetti A, Protti N, Gomez-Vallejo V, Baz Z, Kumar V, Sanchez-Iglesias A, Altieri S, Cossio U, Di Silvio D, Martinez-Villacorta AM, de Angulo AR, Rejc L, Liz-Marzan LM, Llop J.
In Vivo Evaluation of Multifunctional Gold Nanorods for Boron Neutron Capture and Photothermal Therapies
ACS Appl. Mater. Interfaces , 13(42) :49589-49601
17. Llop J, Lammers T.
Nanoparticles for Cancer Diagnosis, Radionuclide Therapy and Theranostics
ACS Nano , 15(11): 16974-16981
16. Cotrina EY, Santos LM, Rivas J, Blasi D, Leite JP, Liz MA, Busquets MA, Planas A, Prohens R, Gimeno A, Jimenez-Barbero J, Gales L, Llop J, Quintana J, Cardoso I, Arsequell G.
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
Eur. J. Med. Chem, 226: 113847
15. Llop J, Trevorrow P.
Meet our advisors: Jordi Llop
J. Labelled Compd. Radiopharm , 64 (13) : 497-499
14. Feiner IV, Longo B, Gómez-Vallejo V, Calvo J, Chomet M, Vugts DJ, Windhorst AD, Padro D, Zanda M, Rejc L, Llop J.
Comparison of analytical methods for antibody conjugates with application in nuclear imaging - Report from the trenches
Nucl Med Biol , 102-103: 24-33
13. Andreozzi P, Simó C, Moretti P, Porcel JM, Lüdtke TU, Ramirez MdlA, Tamberi L, Marradi M, Amenitsch H, Llop J, Ortore MG, Moya SE.
Novel Core-Shell Polyamine Phosphate Nanoparticles Self-Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time
Small, 10.1002/smll.202102211
12. Bindini E, Ramirez MdlA, Ríos X, Cossío U, Simó C, Gómez-Vallejo V, Soler-Illia G, Llop J, Moya SE.
In Vivo Tracking of the Degradation of Mesoporous Silica through Zr-89 Radio-Labeled Core-Shell Nanoparticles
Small, 10.1002/smll.202101519
11. Diez-Alarcia R, Muguruza C, Rivero G, García-Bea A, Gómez-Vallejo V, Callado LF, Llop J, Martín A, Meana JJ.
Opposite alterations of 5-HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
Translational Psychiatry, 11 (1): 302
10. Navascuez M, Gracia R, Marradi M, Diaz N, Rodriguez J, Loinaz I, Lopez-Gallego F, Llop J, Dupin D.
Interfacial activity of modified dextran polysaccharide to produce enzyme-responsive oil-in-water nanoemulsions dagger
Chem. Commun., 37
9. Rejc L, Gómez-Vallejo V, Joya A, Moreno O, Egimendia A, Castellnou P, Ríos-Anglada X, Cossío U, Baz Z, Passannante R, Tobalina-Larrea I, Ramos-Cabrer P, Giralt A,Sastre M,Capetillo-Zarate E, Kosak U, Knez D, Gobec S, Marder M, Martin A, Llop J.
Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
Theranostics, 11 (13): 6542-6559
8. Zhang YJ, Garcia-Gabilondo M, Grayston A, Feiner IVJ, Anton-Sales I, Loiola RA, Llop J, Ramos-Cabrer P, Barba I, Garcia-Dorado D, Gosselet F, Rosell A, Roig A.
PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities
Nanoscale, 13 (5): 3306-3306
7. Pulagam KR, Gómez-Vallejo V, López-Gallego F, Rejc L, Llop J.
Handbook of Radiopharmaceuticals: Methodology and Applications, 2nd Edition.
Handbook of Radiopharmaceuticals: Methodology and Applications , 109-142
6. Ferrer-Ugalde A, Sandoval E, Pulagam KR, Muñoz-Juan A, Laromaine A, Llop J, Tobias G, Núñez R
Radiolabeled Cobaltabis(dicarbollide)anion-graphene oxide nanocomposites for in vivo bioimaging and boron delivery.
ACS Appl. Nano Mater., 4(2):1613-1625
5. Castro-Balado A, Mondelo-García C, Barbosa-Pereira L, Varela-Rey I, Novo-Velerio I, Vázquez-Agra N, Antúnez-López JR, Bandín-Vilar EJ, Sendón-García R, Busto-Iglesias M, Rodríguez-Bernaldo de Quirós A, García-Quintanilla L, González-Barcia M, Zarra-Ferro I, Otero-Espinar FJ, Rey-Bretal D, Lago-Quinteiro JR, Valdés-Cuadrado L, Rábade-Castedo C, del Río-Garma MC, Crespo-Diz C, Delgado-Sánchez O, Aguiar P, Barbeito-Castiñeiras G, Pérez del Molino-Bernal ML, Trastoy-Pena R, Passannante R, Llop J, Pose-Reino A, Fernández-Ferreiro A
Development and characterization of inhaled ethanol as a novel pharmacological strategy currently evaluated in a Phase II clinical trial for early-stage SARS-CoV-2 infection
Pharmaceutics , 13(3):342
4. Hortelao AC, Sanchez S, Simó C, Guix M, Guallar-Garrido S, Julián E, Vilela D, Rejc L, Ramos-Cabrer P, Cossío U, Gómez-Vallejo V, Patiño T, Llop J
Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder
Science robotics , 6(52):10.1126
3. Feiner IVJ, Pulagam KR, Uribe KB, Passannante R, Simó C, Zamacola K, Gómez-Vallejo V, Herrero-Álvarez N, Cossío U, Baz Z, Caffarel MM, Lawrie CH, Vugts DJ, Rejc L, Llop J
Pretargeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy.
Journal of materials chemistry B. , 9(2):410-420.
2. Groult H, Carregal-Romero S, Castejón D, Azkargorta M, Miguel-Coello A, Pulagam KR, Gómez-Vallejo V, Cousin R, Muñoz-Caffarel M, Lawrie CH, Llop J, Piot J, Elortza F, Maugard T, Ruiz-Cabello J, Fruitier-Arnaudin I.
Heparin length in the coating of extremely small iron oxide nanoparticles regulates in vivo theranostic applications.
Nanoscale , 13: 842-861
1. Joya A, Ardaya M, Montilla A, Garbizu M, Plaza-García S, Gómez-Vallejo V, Padró D, Gutierrez JJ, Ríos X, Ramos-Cabrer P, Cossío U, Pulagam KR, Higuchi M, Domercq M, Cavaliere F, Matute C, Llop J. Martín A.
In vivo multimodal imaging of adenosine A(l) receptors in neuroinflammation after experimental stroke.
Theranostics , 11(1):410-425
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2020


19. Zhang YJ, Garcia-Gabilondo M, Grayston A, Feiner IVJ, Anton-Sales I, Loiola RA, Llop J, Ramos-Cabrer P, Barba I, Garcia-Dorado D, Gosselet F, Rosell A, Roig A.
PLGA protein nanocarriers with tailor-made fluorescence/MRI/PET imaging modalities.
Nanoscale, 12: 4988
18. Cotrina EY, Gimeno A, Llop J, Jiménez-Barbero J, Quintana J, Prohens R, Cardoso I, Arsequell G.
An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act as Chaperones of the Transthyretin and Amyloid-beta Peptides Interaction.
Chem. Eur. J , 26 (72):17462-17469
17. Van der Weide H, Cossío, U, Gracia R, te Welscher YM, ten Kate MT, van der Meijden A, Marradi M, Ritsema JAS, Vermeulen-de Jongh DMC, Storm G, Goessens WHF, Loinaz I, van Nostrum CF, Llop J, Hays JP, Bakker-Woudenberg IAJM.
Therapeutic Efficacy of Novel Antimicrobial Peptide AA139-Nanomedicines in a Multidrug-Resistant Klebsiella pneumoniae Pneumonia-Septicemia Model in Rats
Antimicrob Agents Ch , 64
16. Cotrina EY, Oliveira A, Leite JP, Llop J, Gales L, Quintana J, Cardoso I, Arsequell G.
Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer
Int. J. Mol. Sci, 21
15. Feiner IVJ, Pulagam KR, Gómez-Vallejo V, Zamacola K, Baz Z, Caffarel MM, Lawrie CH, Ruiz-de-Angulo A, Carril M, Llop J.
Therapeutic Pretargeting with Gold Nanoparticles as Drug Candidates for Boron Neutron Capture Therapy
Part Part Syst Char, 2000200
14. Ruiz-de-Angulo A, Bilbao-Asensio M, Cronin J, Evans SJ, Clift MJ, Llop J, Feiner IV, Beadman R, Bascarán KZ, Mareque-Rivas JC.
Chemically Programmed Vaccines: Iron Catalysis in Nanoparticles Enhances Combination Immunotherapy and Immunotherapy-Promoted Tumor Ferroptosis
iScience, 23:101499
13. Zanda M, Colombano A, Dall Angelo S, Kingston L, Grönberg G, Correia C, Passannante R, Baz Z, Morcillo MA, Elmore C, Llop J.
Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation
ChemMedChem, 4
12. Rejc L, Gómez-Vallejo V, Ríos X, Cossío U, Baz Z, Mujica E, Gião T, Cotrina EY, Jiménez-Barbero J, Quintana J, Arsequell G, Cardoso I, Llop J.
Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-ß Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study
J Alzheimers Dis., 77
11. Ardaya M, Joya A, Padro D, Plaza-García S, Gómez-Vallejo V, Sánchez M, Garbizu M, Cossío U, Matute C, Cavaliere F, Llop J, Martín A.
In vivoPET Imaging of Gliogenesis After Cerebral Ischemia in Rats
Front. Neurosci, 14
10. Guarra F, Terenzi A, Pirker C, Passannante R, Baier D, Zangrando E, Gómez V, Biver T, Gabbiani C, Berger W, Llop J, Salassa L.
I-124 Radiolabeling of a Au-III-NHC Complex for In Vivo Biodistribution Studies
Angew. Chem. Int. Ed, 59
9. van Moolenbroek GT, Patiño T, Llop J, Sánchez S.
Engineering Intelligent Nanosystems for Enhanced Medical Imaging
Adv. Intell. Syst., 2000087
8. Navascuez M, Dupin D, Jürgen-Grande H, Gómez-Vallejo V, Loinaz I, Cossío U, Llop J
COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs
Chem. Commun., 56
7. Gião T, Saavedra J, Cotrina E, Quintana J, Llop J, Arsequell G, Cardoso I.
Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease.
Int. J. Mol. Sci., 21
6. Cotrina EY, Gimeno A, Llop J, Jiménez-Barbero J, Quintana J, Valencia G, Cardoso I, Prohens R, Arsequell G.
Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, A beta Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
J. Med. Chem., 63
5. Falciani C, Zevolini F, Brunetti J, Riolo G, Gracia R, Marradi M, Loinaz I, Ziemann C, Cossío U, Llop J, Bracci L, Pini A.
Antimicrobial Peptide-Loaded Nanoparticles as Inhalation Therapy for Pseudomonas aeruginosa Infections.
Int. J. Nanomed, 15
4. Videira MA, Llop J, Sousa C, Kreutzer B, Cossío U, Forbes B, Vieira I, Gil N, Silva-Lima B.
Pulmonary Administration: Strengthening the Value of Therapeutic Proximity.
Front. Med., 7
3. Pulagam KR, Gómez-Vallejo V, Llop J, Rejc L.
Radiochemistry: A Useful Tool in the Ophthalmic Drug Discovery.
Curr Med Chem, 27: 501-522
2. Zhang Y, García-Gabilondo M, Grayston A, Feiner I, Anton-Sales I, Loiola RA, Llop J, Ramos-Cabrer P, Barba I, García-Dorado D, Gosselet F, Rosell A, Roig A.
PLGA protein nanocarrier with made-to-order fluorescence/MRI/PET imaging modalities.
Nanoscale, 8
1. Tripathi A, Rode CV, Llop J, Chavan SP, Joshi SM.
An enolate-mediated regioselective synthesis of 1,2,3-triazoles via azidealdehydes or ketones [3+2]-cycloaddition reactions in aqueous phase
Tetrahedron Letters, 61:13
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2019


13. Holzwarth U, Cossío U, Llop J, Kreyling WG.
Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies.
Front. Pharmacol., 10: 1293
12. Pulagam k, Gona K, Gómez-Vallejo V, Meijer J, Zilberfain C, Estrela-Lopis I, Baz Z, Cossío U, Llop J.
Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In Vivo Evaluation.
Molecules, 24: 3609
11. Latorre-Pellicer A, Lechuga-Vieco AV, Johnston IG, Hämäläinen RH, Pellico J, Justo-Méndez R, Fernández-Toro JM, Clavería C, Guaras A, Sierra R, Llop J, Torres M, Criado LM, Suomalainen A, Jones, NS, Ruiz-Cabello J,Enríquez JA.
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy.
Cell Metab, 30: 1120-1130
10. Ríos X, Gómez-Vallejo V, Martín A, Cossío U, Morcillo MA, Alemi M, Cardoso I, Quintana J, Jimenez-Barbero J, Cotrina EY, Valencia G, Arsequell G, Llop J.
Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Sci. Rep., 9: 13672
9. Martín A, Joya A, Plaza-García S, Gómez-Vallejo V, Padro D, Ramos-Cabrer P, Cossío U, Pulagam KR, Llop J.
In vivo Imaging of adenosine A1 receptors in neuroinflammatory response after experimental stroke
J. Cereb. Blood Flow Metab., 39: 532-533.
8. Muzzio NE, Pasquale MA, Ríos X, Azzaroni O, Llop J, Moya SE.
Cell-Interface Interactions: Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion
Adv. Mater. Interfaces , 6: 1970049
7. Díez-Alarcia R, Muguruza C, Rivero G, García-Bea A, Callado LF, Martín A, Llop J, Meana JJ.
Human cerebral 5-HT2A receptor labelling with [18F]altanserin, [3H]LSD, and [3H]M100907. Relevance of radiotracer intrinsic activity
Eur Neuropsychopharm , 29: S324-S324
6. Gómez-Vallejo V, Rejc L, López-Gallego F, Llop J.
The radiopharmaceutical chemistry of nitrogen-13 and oxygen-15
Radiopharmaceutical Chemistry , 237-254
5. Pulagam KR, Gómez-Vallejo V, Llop J, Rejc L.
Radiochemistry; A useful tool in the ophthalmic drug discovery
Curr. Med. Chem. , 26
4. Alonso-de Castro S, Ruggiero E, Lekuona Fernández A, Cossío U, Baz Z, Otaegui D, Gómez-Vallejo V, Padro D, Llop J, Salassa L.
Functionalizing NaGdF4:Yb,Er Upconverting Nanoparticles with Bone-Targeting Phosphonate Ligands: Imaging and In Vivo Biodistribution.
Inorganics , 7:60
3. Ríos X, Compte M, Gómez-Vallejo V, Cossío U, Baz Z, Morcillo M.A., Ramos-Cabrer P, Alvarez-Vallina L, Llop J.
Immuno-PET imaging and pharmacokinetics of an anti-CEA scFv-based trimerbody and its monomeric counterpart in human gastric carcinoma-bearing mice
Molecular pharmaceutics , DOI: 10.1021/acs.molpharmaceut.8b01006
2. Muzzio N, Pasquale M, Ríos X, Azzaroni O, Llop J, Moya S.
Adsorption and Exchangeability of Fibronectin and Serum Albumin Protein Corona on Annealed Polyelectrolyte Multilayers and Their Consequences on Cell Adhesion
Advanced Materials Interfaces , DOI: 10.1002/admi.201900008
1. Royo F, Cossío U, Ruiz de Angulo A, Llop J, Falcon-Perez JM.
Modification of the glycosylation of extracellular vesicles alters their biodistribution in mice
Nanoscale, 11: 1531-1537
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2018


13. Pio Di Mauro1 P, Cascante A, Brugada Vilá P, Gómez-Vallejo V, Llop J, Borrós S.
Peptide-functionalized and high drug loaded novel nanoparticles as dualtargeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma
International Journal of Pharmaceutics, 553: 169-185
12. Joya A, Padró D, Gómez-Vallejo V, Plaza-García S, Llop J, Martín A.
PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats.
Imaging, 2483078
11. Zabala A, Vázquez-Villoldo N, Rissiek B, Gejo J, Martín A, Palomino A, Perez-Samartín A, Pulagam KR, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M.
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
EMBO Mol. Med, 10.1039/C6TB02773C
10. Gómez-Vallejo V, Puigivila M, Plaza-García S, Szczupak B, Piñol R, Pola JL, Sorribas V, Lou G, Veintemillas-Verdaguer S, Ramos-Cabrer P, Llop J, Millán A.
PEG-Copolymer-coated Iron Oxide Nanoparticles that Avoid the Reticuloendothelial System and Act as Kidney MRI Contrast Agents
Nanoscale, 10.1039/C8NR03084G
9. Cossío U, Gómez-Vallejo V, Flores M, Gañán-Calvo B, Jurado G, Llop J.
Preclinical evaluation of aerosol administration systems using Positron Emission Tomography
Eur. J. Pharm. Biopharm., 130: 59-65
8. Rejc L, Gómez-Vallejo V, Alcazar J, Alonso N, Andrés JI, Arrieta A, Cossío FP, Llop J.
Negishi coupling reactions with [C-11]CH3I: a versatile method for efficient C-11-C bond formation
Chem. Commun., 54: 4401-4398
7. Gondan AIB, Ruiz-de-Angulo A, Zabaleta A, Blanco NG, Cobaleda-Siles BM, García-Granda MJ, Padro D, Llop J, Arnaiz B, Gato M, Escors D, Mareque-Rivas JC.
Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles
Biomaterials, 170: 115-95
6. Colás L, Domercq M, Ramos-Cabrer P, Palma A, Gómez-Vallejo V, Padro D, Plaza-García S, Pulagam KR, Higuchi M, Matute C, Llop J, Martín A.
In vivo imaging of A7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia
GLIA, 2018
5. Lizal F, Jedelsky J, Morgan k, Bauer K, Llop J, Cossío U, Kassinos S, Verbanck S, Ruiz-Cabello J, Santos A, Koch E, Schnabel C.
Experimental methods for flow and aerosol measurements in human airways and their replicas
European Journal of Pharmaceutical Sciences, 113 : 95-131
4. da Silva E.S,Gómez-Vallejo V, López-Gallego F, Llop J.
Biocatalysis in Radiochemistry; Enzymatic Incorporation of PET radionuclides into molecules of biomedical interest
Journal of Labelled Compounds & Radiopharmaceuticals, 61 : 332-354
3. Vilela D, Cossio U , Parmar J, Martínez-Villacorta A.M, Gómez-Vallejo V, Llop J, Sánchez S.
Medical Imaging for the Tracking of Micromotors
ACS Nano, 12 (2): 1220-1227
2. Erice O, Labiano I, Arbelaiz A, Santos-Laso A, Munoz-Garrido P, Jimenez-Aguero R, Olaizola P, Caro-Maldonado A, Martín-Martín N, Carracedo A, Lozano E, Marin JJ, O'Rourke CJ, Andersen JB, Llop J, Gómez-Vallejo V, Padro D, Martín A, Marzioni M, Adorini L, Trauner M, Bujanda L, Perugorria MJ, Banales JM.
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
BBA Molecular Basis of Disease, 1864 : 1335-1344
1. Velasco-Lozano S, da Silva E.S, Llop J, López-Gallego F.
Sustainable and continuous synthesis of enantiopure L-amino acids using a versatile immobilised multi-enzyme system
ChemBioChem, 19(4):395-403
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2017


11. Pellico J, Llop J, Fernández-Barahona I, Bhavesh R, Ruiz-Cabello J, Herranz F.
. Iron Oxide Nanoradiomaterials: Combining Nanoscale Properties with Radioisotopes for Enhanced Molecular Imaging
Contrast Media & Molecular Imaging, 2017 (2017), Article ID 1549580
10. Pulagam KR, Colás L, Padro D, Plaza-García S, Gómez-Vallejo V, Higuchi M, Llop J, Martín A.
Evaluation of the novel TSPO radiotracer [F-18] VUIIS1008 in a preclinical model of cerebral ischemia in rats
EJNMMI Research, 7(93)
9. Dimchevska S, Geskovski N, Koliqi R, Matevska-Geskovska N, Gómez Vallejo V, Szczupak B, Sebastian ES, Llop J, Hristov DR, Monopoli MP, Petrusevski G, Ugarkovic S, Dimovski A, Goracinova K.
Efficacy assessment of self-assembled PLGA-PEG-PLGA nanoparticles: Correlation of nano-bio interface interactions, biodistribution, internalization and gene expression studies.
International Journal of Pharmaceutics, 533 (2): 389-401
8. Gimeno A,Santos LM, Alemi M, Rivas J, Blasi D, Cotrina EY, Llop J, Valencia G, Cardoso I, Quintana J, Arsequell G, Jiménez-Barbero J.
Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal
Journal of Medicinal Chemistry, 60 (13): 5749-5758
7. Joshi S, Mane RB, Pulagam K, Gómez-Vallejo V, Llop J, Rode CV.
Microwave assisted synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition over heterogeneous Cu based catalyst: Application to the preparation of 13N-labelled tetrazoles
New Journal of Chemistry, 41 (16):8084-8091
6. Koziorowski J, Stanciu AE, Gómez-Vallejo V, Llop J.
Radiolabeled nanoparticles for cancer diagnosis and therapy
Anticancer agents in medicinal chemistry, 17(3):333-354
5. Luque-Michel E, Sebastian V, Szczupak B, Imbuluzqueta E, Llop J, Blanco Prieto MJ.
Visualization of hybrid gold-loaded polymeric nanoparticles in cells using scanning electron microscopy
Journal of Drug Delivery Science and Technology, 42 :315-320
4. da Silva ES, Gómez-Vallejo V, Llop J, López-Gallego F.
Structural, kinetic and operational characterization of an immobilized l-aminoacid dehydrogenase
Process Biochemistry, 57:80-86
3. Heinz H, Pramanik C, Heinz O, Ding Y, Mishra RK, Marchon D, Flatt RJ, Estrela-Lopis I, Llop J, Moya S.
Nanoparticle decoration with surfactants: Molecular interactions, assembly, and applications
Surface Science Reports, 72(1):1-58
2. Pottier G, Gómez-Vallejo V, Padro D, Boisgard R, Dollé F, Llop J, Winkeler A, Martín A.
PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats
JCBFM, 37(3):1163-1178
1. Gracia R, Marradi M, Cossío U, Benito A, Pérez-San Vicente A, Gómez-Vallejo V, Grande HJ, Llop J, Loinaz I.
Synthesis and Functionalization of Dextran Based Single Chain Nanoparticles in Aqueous Media
Journal of Materials Chemistry B, 10.1039/C6TB02773C
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2016


11. Llop J, Marradi M, Jiang P, Gómez-Vallejo V, Baz Z, Echeverría M, Gao C, Moya SE.
In vivo stability of protein coatings on poly lactic co glycolic nanoparticles
MRS Advances, 1(56):3767-3773
10. Joshi SM, Gómez-Vallejo V, Salinas V, Llop J.
Synthesis of 13N-labelled polysubstituted triazoles via Huisgen cycloaddition
Theranostics, 6(11):1753-1767
9. Domercq, M. Szczupak, B. Gejo, J. Gómez-Vallejo, V. Padro, D. Gona, KB. Dollé, F. Higuchi, M. Matute, C. Llop, J. Martín, A.
PET imaging with [18F]FSPG evidences the role of system xc- on brain inflammation following cerebral ischemia in rats.
RSC Advances, 51(43):8954-8957
8. Gómez-Vallejo V, Lekuona A, Baz Z, Szczupak B, Cossío U, Llop J.
Ion beam induced 18F-radiofluorination: Straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography
Chem Comm, 52(80):11931-11934
7. Benito AB, Aiertza M, Marradi M, Gil-Iceta L, Shekhter Zahavi T, Szczupak B, Jiménez-González M, Reese T, Scanziani E, Passoni L, Matteoli M, De Maglie M, Orenstein A, Oron-Herman M, Kostenich G, Buzhansky L, Gazit E, Grande HJ, Gómez-Vallejo V, Llop J, Loinaz I.
Functional single-chain polymer nanoparticles: Targeting and imaging pancreatic tumors in vivo
BioMacromolecules, 17(10):3213-3221
6. Da Silva E, Gómez-Vallejo V, Baz Z, Llop J, López-Gallego F.
Efficient enzymatic preparation of 13N-labelled amino acids:Towards multipurpose synthetic systems
Chemistry European Journal, 22(38):13619-13626
5. Brunetti J, Falciani C, Roscia G, Pollini S, Bindi S, Scali S, Cossío U, Gómez-Vallejo V, Quercini L, Ibba E, Prato M, Rossolini GM, Llop J, Bracci L, Pini A.
In vitro and in Vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate
Scientific Reports, 6,26077
4. Ruiz de Angulo A, Zabaleta A, Gómez-Vallejo V, Llop J, Mareque-Rivas J.
Microdosed lipid-coated 67Ga_magnetite enhances antigen-specific immunity by SPECT/CT-image tracked delivery of antigen and CpG to lymph nodes
ACS Nano, 10:1602-1618
3. Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastian E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MA, Martin A, Lizasoain I.
Imaging the role of TLR4 on cell proliferation and inflammation after cerebral ischemia by PET
Journal of cerebral blow flow and metabolism, 36(4):702-708
2. Gómez-Vallejo V, Ugarte A, García-Barroso C, Cuadrado-Tejedor M, Szczupak B, Dopeso-Reyes IG, Lanciego JL, García-Osto A, Llop J, Oyarzabal J, Franco R.
Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels
Journal of neurochemistry, 136: 403-415
1. Martín A, Vázquez-Villoldo N, Gómez-Vallejo V, Padró D, Soria FN, Szczupak B, Plaza-García S, Arrieta A, Reese T, Llop J, Domercq M, Matute C.
In vivo imaging of system sc-as a novel approach to monitor multiple sclerosis
European Journal of nuclear medicine and molecular imaging, 43(6):1124-1138
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2015

9. Simoes AVC, Pinto SMA, Calvete MJF, Gomes CMF, Ferreira NC, Castelo-Branco M, Llop J, Pereira MM, Abrunhosa A.
Synthesis of a new 18F labeled porphyrin for potential application in positron emission tomography. In vivo imaging and cellular uptake
RSC Advances, 5: 99540-99546
8. Martín A, Szczupak B, Gómez-Vallejo V, Domercq M, Cano A, Padro D, Muñoz C, Higuchi M, Matute C, Llop J.
In vivo PET imaging of the α4β2 nicotinic acetylcholine receptor as a marker for brain inflammation after cerebral ischemia
Journal of Neurosciences, 35(15): 5998-6009
7. López de Laorden C, Beloqui A, Yate L, Calvo J, Puigivila M, Llop J, Reichardt N.
Nanostructure indium tin oxide slides for small molecules profiling and imaging mass spectrometry of metabolites by surface-assisted laser desorption ionization MS
Analytical Chemistry, 87: 431-440
6. Di Mauro PP, Gómez-Vallejo V, Baz Z, Llop J, Borrós S.
Novel 18F-labeling strategy for polyester-based NPs for in vivo PET-CT imaging
Bioconjugate chemistry, 26(3): 582-592
5. Gona KB, Lakshmi VPN Thota J, Baz Z, Gómez-Vallejo V, Llop J.
Synthesis and 11C-radiolabelling of 2-carboranyl benzothiazoles
Molecules, 20: 7495-7508.
4. Da Silva ES, Gómez-Vallejo V, Llop J, López-Gallego F.
Efficient nitrogen-13 radiochemistry catalyzed by a highly stable immobilized biocatalyst
Catalysis science and technology, 5: 2705-2713
3. Joshi SM, de Cozar A, Gómez-Vallejo V, Koziorowski J, Llop J, Cossio F.
Synthesis of radiolabelled aryl azides from diazonium salts: experimental and computational results permit to identify the preferred mechanism
Chem Comm, 51: 8954-8957
2. Gona KB, Lakshmi VPN Thota J, Baz Z, Gómez-Vallejo V, Llop J.
Straightforward synthesis of radioiodinated Cc-substituted o-carboranes: towards a versatile platform to enable in vivo assessment of BNCT drug candidates
Dalton Transactions, 44: 9915-9920
1. Llop J, Jiang P, Marradi M, Gómez-Vallejo V, Echeverría M, Yu S, Puigivila M, Baz Z, Szczupak B, Pérez-Campañ;a C, Mao Z, Gao C, Moya SE.
Visualising dual radiolabelled poly(lactide-co-glycolide) nanoparticle degradation in vivo using energy-discriminant SPECT
Journal of Materials Chemistry B, 3: 6293-6300
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2014

14. Pérez-Campaña C, Sansaloni F, Gómez-Vallejo V, Baz Z, Martín A, Moya SE, Lagares JI, Ziolo RF, Llop J.
Production of 18F-labeled titanium nanoparticles by proton irradiation for biodistribution and biological fate studies in rats
Particle and particle and system characterization, 31: 134-142
13. Vázquez N, Domercq M, Martín A, Llop J, Gómez-Vallejo V; Matute, C.
P2X4 receptors control the fate and survival of activated microglia
Gliaem, 62(2): 171-184
12. Llop J, Estrela-Lopis I, Ziolo RF, González A, Fleddermann J, Dorn M, Gómez-Vallejo V, Simón-Vázquez R, Donath E, Mao Z, Gao C, Moya S.E.
Uptake, biological fate, and toxicity of metal oxide nanoparticles
Particle and Particle and system characterization, 31: 24-35
11. Gómez-Vallejo V, Vázquez N, Gona KB, Puigivila M, González M, San Sebastián E, Martín A, Llop J.
Synthesis and in vivo evaluation of 11C-labeled (1,7-dicarba-closo-dodecaboran-1-yl)-N-{[(2S)-1-ethylpirrolidin-2-yl]methyl}amide
Journal of labeled compounds and radiopharmaceuticals, 57: 209-214
10. Gaja V, Gómez-Vallejo V, Puigivila M, Pérez-Campaña C, Martín A, García-Osta A, Calvo-Fernández T, Cuadrado-Tejedor M, Franco R, Llop J.
Synthesis and evaluation of 13N-labelled azo compounds for β-amyloid imaging in mice
Molecular imaging and biology, 16: 538-549
9. Frigell J, García I, Gómez-Vallejo V, Llop J, Penadés S.
68Ga-labeled gold glyconanoparticles for exploring blood brain barrier permeability: Preparation, Biodistribution Studies, and Improved Brain Uptake via neuropeptide conjugation
Journal of American Chemical Society, 136(1): 449-457
8. Locatelli E, Bost W, Fournelle M, Llop J, Gil L, Arena F, Lorusso V, Comes Franchini M.
Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach
Journal of nanoparticle research, 16: 2304-2307
7. Gómez-Vallejo V, Gaja V, Gona KB, Llop J.
Efficient nitrogen-13 radiochemistry catalyzed by a highly stable immobilized biocatalyst
Journal of labeled compounds and radiopharmaceuticals, 57: 244-254
6. Infante A, Gago A, Ruiz de Eguino G, Calvo-Fernández T, Gómez-Vallejo V, Llop J, Schlangen K, Fullaondo A, Aransay AM, Martín A, Rodríguez CI.
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell
Aging, 6: 264-280
5. Soria FN, Pérez-Samartín A, Martín A, Gona KG, Llop J, Szczupak B, Chara JC, Matute C, Domercq M.
Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage
The Journal of clinical Investigation, 124: 3645-3655
4. Cobaleda-Siles, M; Henriksen-Lacey, M; Ruiz de Angulo, A; Bernecker A, Gómez-Vallejo V, Szczupak B, Llop J, Pastor G, Plaza-García S, Jauregui-Osoro M, Meszaros LK, Mareque-Rivas JC.
Theranostics: An iron oxide nanocarrier for dsRNA to target lymph nodes and strongly activate cells of the immune system
Small, 10(24): 5053
3. Cobaleda-Siles, M; Henriksen-Lacey, M; Ruiz de Angulo, A; Bernecker A, Gómez-Vallejo V, Szczupak B, Llop J, Pastor G, Plaza-García S, Jauregui-Osoro M, Meszaros LK, Mareque-Rivas JC.
An iron oxide nanocarrier for dsRNA to target lymph nodes and strongly activate cells of the immune system
Small, 10(24): 5054-5067
2. Gona KB, Zaulet A, Gómez-Vallejo V, Teixidor F, Llop J, Viñas C.
COSAN as a molecular imaging platform: synthesis and in vivo imaging
Chem Comm, 50: 11415-11417
1. Gómez-Vallejo V, Baz Z, Llop J.
Desarrollo de nuevas sondas de imagen molecular.
RADIOPROTECCIÓN: revista de la sociedad española de protección radiológica., 79: 60-70
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2013

9. Martín A, Gómez-Vallejo V, San Sebastián E, Padró D, Markuerkiaga I, Llarena I, Llop J.
68In vivo imaging of dopaminergic neurotransmission after transient focal ischemia in rats
Journal of Cerebral Blood Flow and metabolism, 33: 244-252
8. Torrent E, Farré M, Abasolo I, Millan O, Llop J, Gispert JD, Ruiz A, Pareto D.
Optimization of [11C]raclopride positron emission tomographic rat studies: comparison of methods for image quantification
Molecular Imaging Journal, 12(4): 257-262
7. Sansaloni F, Lagares JI, Llop J, Arce P, Díaz C, Pérez-Morales JM.
Production of [11C]CO2 with gas target at low proton energies
Applied radiation and isotopes, 78: 10-15
6. Pérez-Campaña C, Gómez-Vallejo V, Puigivila M, Martín A, Calvo-Fernández T, Moya SE, Ziolo RF, Reese T, Llop J.
Biodistribution of different size nanoparticles assessed by positron emission tomography: a general strategy for direct activation of metal oxide particles
ACS Nano, 7(4): 3498-3505
5. Llop J, Gómez-Vallejo V, Gibson N.
Quantitative determination of the biodistribution of nanoparticles: could radiolabeling be the answer?
Nanomedicine, 8(7): 1-4
4. Pérez-Campaña C, Gómez-Vallejo V, Puigvila M, Martin A, Calvo-Fernández T, Moya SE, Larsen ST, Gispert JD, Llop J.
Assessing lung inflammation after nanoparticle inhalation using 2-deoxy-2-[18F]-fluoro-d-glucose positron emission tomography imaging
Molecular Imaging and biology, 16: 264-273
3. Martín A, Szczupak B, Gómez-Vallejo V, Plaza S, Padró D, Cano A, Llop J.
PET imaging of serotoninergic neurotransmission with [11C]DASB and [18F]altanserin after focal cerebral ischemia in rats
Journal of cerebral blood flow and metabolism, 33: 1967-1975
2. Itsenko O, Gómez-Vallejo V, Llop J, Koziorowski J.
On 11C chemistry reviews: surveying and filling the gaps
Current Organic Chemistry, 17: 2067-2096
1. Gona KB, Gómez-Vallejo V, Padro D, Llop J.
[18F]Fluorination of o-carborane via nucleophilic substitution: towards a versatile platform for the preparation of 18F-labelled BNCT drug candidates
Chemical Communications, 49(98): 11491-11493
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2012

9. Martín A, San Sebastián E, Gómez-Vallejo V, Llop J.
68Positron emission tomograghy with [13N]ammonia evidences long-term cerebral hyperperfusion after 2h-transient focal ischemia
Neuroscience, 213: 47-53
8. Vázquez N, Gómez-Vallejo V, Llop J.
Synthesis of novel pyrazole derivatives incorporating one dicarba-closo-dodecaborane unit
Tetrahedron Letters, 53: 4743-4746
7. Aginagalde M, Gómez-Vallejo V, Vara Y, Cossío FP, Llop J.
Synthesis of 11C-labeled kendine-91, a histone deacetylase inhibitor
Applied radiation and isotopes, 70: 2552-2557
6. Gómez-Vallejo V, Martín A, Aginagalde M, San Sebastian E, Padro D, Cossío FP, Llop J.
Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats
Applied Radiation and Isotopes, 70: 2545-2551
5. Gaja V, Gómez-Vallejo V, Cuadrado M, Borrell JI, Llop J.
Synthesis of 13N-labelled radiotracers using microfluidic technology
Journal of Labelled Compounds and Radiopharmaceuticals, 55: 332-338
4. Pérez-Campaña C, Gómez-Vallejo V, Martín A, San Sebastian E, Moya SE, Reese T, Ziolo RF, Llop J.
Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Analyst, 137: 4902-4906
3. Locatelli E, Gil L, Israel LL, Passoni L, Naddaka M, Pucci A, Reese T, Gómez-Vallejo V, Milani P, Mattioli M, Llop J, Lellouche JP, Franchini MC.
Biocompatible nanocomposite for PET/MRI hybrid imaging
Journal of Nanomedicine, 2012(7): 6021-6033
2. Gómez-Vallejo V, González M, Llop J.
Facile and improved synthesis of [11C]Me-QNB
Journal of Labelled Compounds and Radiopharmaceuticals, 55: 470-473
1. Sansaloni F, Lagares JI, Arce P, Llop J, Pérez JM.
Characterization of the proton beam from an IBA Cyclone 18/9 with radiochromic film EBT2
AIP Conference Proceedings, 2013: 46-50
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Past Activity

14. Gómez V, Amador V, Gispert JD, Llop J.
New Method for Routine Production of L-[Methyl]methionine: In Loop Synthesis
Journal Labelled Compounds and Radiopharmaceuticals, 51(1): 83-86, 2008
13. Llop J, Gómez-Vallejo V, Bosque M, Quincoces G, Peñuelas I.
Synthesis of S-[13N]Nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent
Applied Radiation and Isotopes, 67: 95-99, 2009
12. Gómez-Vallejo V, Kato K, Oliden I, Calvo J, Baz Z, Borrell JI, Llop J.
Fully automated synthesis of 13N-nitrosothiols
Tetrahedron Letters, 51: 2990-2993, 2009
11. Gómez-Vallejo V, Llop J.
Specific activity of [11C]CH3I synthesized by the `wet` method: main sources of non-radioactive carbon
Applied Radiation and Isotopes, 67: 111-114, 2009
10. Gómez-Vallejo V, Kato K, Hanyu H, Minegishi K, Borrell JI, Llop J.
Efficient system for the preparation of [13N]Labeled Nitrosamines
Bioorganic and medicinal chemistry Letters, 19: 1913-1915, 2009
9. Martín A, Rojas S, Pareto D, Santalucia T, Millán O, Abasolo I, Gómez V, Llop J, Gispert JD, Falcon C, Bargalló N, Planas AM.
Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: an in vivo positron emission tomography study
Current Neurovascular Research, 6(2): 82-88, 2009
8. Catafau AM, Suarez M, Bullich S, Llop J, et al.
Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET
NeuroImage, 46: 447-458, 2009/strong>
7. Gómez-Vallejo V, Kato K, Oliden I, Calvo J, Baz Z, Borrell JI, Llop J.
Fully automated synthesis of 13N-nitrosothiols
Tetrahedron Letters, 51: 2990-2993, 2010
6. Gómez-Vallejo V, Borrell JI, Llop J.
A convenient synthesis of 13N-labelled azo compounds: a new route for the preparation of amyloid imaging PET probes
European Journal of Medicinal Chemistry, 45: 5318-5323, 2010
5. Figueiras FP, Jiménez X, Pareto D, Gómez V, Llop J, Herance R, Rojas S, Gispert JD.
Simultaneous Dual-tracer PET imaging of the rat brain and its application in the study of cerebral ischemia
Molecular Imaging and Biology, 13(3): 500-510, 2010
4. Vázquez N, Gómez-Vallejo V, Calvo J, Padro D, Llop J.
Synthesis of D2 receptor ligands analogs incorporating one dicarba-closo-dodecaborane unit
Tetrahedron Letters, 52: 615-618, 2011
3. Rojas S, Martín A, Pareto D, Herance JR, Abad S, Ruiz A, Flotats N, Gispert JD, Llop J, Gómez-Vallejo V, Planas AM.
PET with 11C-Flumazenil in the rat shows preservation of binding sites during the acute phase after 2h-transient focal ischemia.
Neuroscience, 182: 208-216, 2011
2. Catafau AM, Bullich S, Nucci G, et al.
Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812
Journal of Nuclear Medicine, 52(4): 526-534, 2011
1. Gómez-Vallejo V, Llop J.
Fully automated and reproducible radiosynthesis of high specific activity [11C]raclopride and [11C]Pittsburg compound-B using the combination of two commercial synthesizers
Nuclear and Medicine Communications, 32 (11): 1011-1017, 2011
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