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Background


The HYMADE project is based on the application of layer-by-layer (LbL) technology for the fabrication of hybrid colloidal systems for drug delivery involving materials of different nature: organic, inorganic and biological. HYMADE seeks to take advantage of the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. The project also seeks to gain understanding of the self assembly process of hybrid materials and the transport properties of drug delivery systems. The biological fate, drug release, degradation and therapeutic efficiency of drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. The materials employed in HYMADE are porous and the drugs can be inserted and then released gradually by modifying the surface of the porous particles using polymers and virus particles. This technique enables better control of the release and targeting of the materials. The capsules and particles developed in the project will have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis.

HYMADE also aims to establish a strong research network between European and non-European institutions through the secondment of Early Stage Researchers and Experienced Researchers, and through the organization of networking, training, and research activities.
To achieve these goals we have gathered an international multidisciplinary team with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Biophysics and Imaging from Germany, Austria, France and Spain on the European side and from United States of America, Argentina and Armenia on the non-European side.

The project partnership is formed by CIC biomaGUNE (Spain), the Austrian Institute of Technology (Austria), the University of Leipzig (Germany), the University Pierre et Marie Curie (France), the University of Michigan (USA), the Yerevan State University (Armenia), the National Commission of Atomic Energy (Argentina), the Research Institute of Theoretical and Applied Physical Chemistry of the National Council of Technical and Scientific Research (INIFTA-CONICET, Argentina) and the National University of General San Martin (Argentina).


This project has received funding from the European Unionís Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 645686